Treatment Marble Bone Disease

Bone marrow transplant is the only complete cure available for malignant marble bone disease.

Treatment marble bone disease.

For patients who have complications surgery may be necessary. Complications of paget s disease of bone can include broken bones hearing loss and pinched nerves in your spine. Corti costeroids high dose calcitriol have been helpful in the treatment of osteopetrosis. Osteopetrosis can cause bones to dissolv.

In pediatric childhood osteopetrosis surgery is sometimes needed because of fractures. Advertisement in cases of osteopetrosis in adults there are no treatments required. What are treatments for osteopetrosis or marble bone disease. A recently published article6 reported on the follow up of seven patients with marble bone disease who had received alkaline therapy.

Bisphosphonates the medications also used to strengthen bones weakened by osteoporosis are the mainstay of treatment. Osteopetrosis literally stone bone also known as marble bone disease or albers schönberg disease is an extremely rare inherited disorder whereby the bones harden becoming denser in contrast to more prevalent conditions like osteoporosis in which the bones become less dense and more brittle or osteomalacia in which the bones soften. Treatment strategies include correcting anemia thrombocytopenia and treating infections. At present the only established cure for autosomal recessive malignant infantile osteopetrosis is hematopoietic stem cell transplantation hsct for specific cases.

This treatment resulted in improvement of growth retardation. Bone marrow transplantation bmt markedly improves some cases of severe infantile osteopetrosis associated with bone marrow failure and offers the best chance of longer term survival for individuals with this type. Therapeutic agents that can be used to treat marble bone disease include gamma interferon a protein that delays progression of the disease or calcitriol a vitamin d compound that stimulates osteoclasts to dissolve and absorb bone. This allows the restoration of bone resorption by donor derived osteoclasts.

Bone marrow transplant and splenectomy may be useful in some patients.